A Critical Analysis of the Role of Serotonin in Suicide.

A serotonergic dysfunction in the brain has been reported to be involved in suicidal behaviour independently of the pram of a specific psychiatric disorder (Mann et al., 1999). The seretonergic receptor cadaver is comprised of fourteen receptor subtypes that ar subdivided into seven families (Raymond et al., 2001). The majority of studies advert cerebrateed on serotonin receptor subtypes, and suffer suggested that any(prenominal) of the receptors whitethorn be especially involved in the pathogenesis of depression, suicidal behaviour, aggression and impulsivity. The beginning part of this essay depart focus on the agency of serotonin, 5-hydroxytryptamine monoamine neurotransmission (5-HT) in self-destruction. More specifically, it will look on the studies of the cerebrospinal fluid (CSF), 5-hydroxyindoleacetic acid (5-HIAA) which is the wizard metabolite of 5-HT in depression. The s part of the essay will check the serotonin receptor abnormalities. It will lo ok at post-mortem receptor-binding studies that indicated abnormalities in the ventral prefrontal cortex of patients who committed suicide. Neurochemical abnormalities The 5-HT has a signalize role in the behaviour of humans and other species, much(prenominal) as impulsivity and aggression.

This is due to the 5-HT systems characteristics; they are the signal mediator for the effects of serotonin which is a sizeable functional distributor of biliousness sensitivity. Many studies of suicide attempters have confirmed abnormalities in 5-HT neurotransmission and the gamble of suicide has been strong ly jibe with the belittled concentration o! f this neurotransmitter. This may be caused by dearths in the uptake of serotonin (Stoff & Mann, 1997). Alterations in neurotransmitter and neuromodulato receptor density could persist an important role in the neurobiological basis of suicide (Bland, 1997). One of the possible causes of low concentration of CSF 5-HIAA can be explained by a deficit in platelet markers (Asberg & Forslund, 2000). However, the link...If you penury to get a estimable essay, order it on our website: OrderCustomPaper.com

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